Abstract: The grade of Al₂O₃ and SiO₂ of a bauxite in southwest China is 56.86% and 14.86% respectively, and the sulfur content is 1.57%. A Synchronous desulfurization and desiliconization experiments were carried out to develop and utilize this bauxite efficiently. The flotation research results show that under the conditions of Na₂CO₃ as pH regulator, CuSO₄ as activator, SNS as inhibitor, BA-1 as desulfurization collector, terpenic oil as frother and EXA as desilication collector, the concentrate of 61.03% Al₂O₃ and 11.95% SiO₂ were achieved after "one roughing-one cleaning-three scavenging" circuit. The sulfur content of concentrate is 0.19% and the rate of aluminum to silicon is 5.11.This process can provide guidance for the utilization of the mine and a new technical idea for the development and utilization of this type of bauxite.