Abstract: Primary rutile ore in China has the characteristics of complex mineral composition, low grade of target mineral and fine disseminated grain size. Flotation is an important means of recovering and utilizing rutile and improving its grade, among which flotation reagent is the key. The collectors of flotation rutile mainly include fatty acid, phosphonic acid, arsine acid and hydroxamic acid, and the regulator can be divided into activator and inhibitor. To promote the progress of rutile mineral processing technology, as well as the theory of ore dressing workers to provide technical reference, based on the overview of the rutile ore properties, micro-nano flotation and flotation difficulties, the research progress and action mechanism of collectors, inhibitors and activators were summarized in detail to deepen the understanding of primary rutile flotation reagents, and the future research directions of reagents were also prospected.