Abstract: In order to study the effects of different concentrations of modifiers (sodium carbonate, calcium chloride and magnesium chloride) on flotation recovery and flotation rate of magnesite and dolomite single minerals the batch bleb flotation test was summarized. For -74+38 μm particles of magnesite and dolomite, set the pulp pH value to 12, the concentration of sodium oleate to 0.25 mmol/L during the flotation test, and the optimum separation process flotation is obtained. The results show that the difference of floatation characteristics between magnesite and dolomite is significant when magnesium chloride (2.0 mmol/L) as a regulator. The flotation separation of two groups is realized by two coarse selection, 1 time for coarse selection is 1.0 min, and 2 time for coarse selection is 4.0 min. The flotation process of magnesite and dolomite can be well simulated by the simulation analysis of the single mineral flotation process of magnesium chloride (2.0 mmol/L) as a regulator.