Abstract: The sulfur-oxygen mixed copper cobalt ore in Katanga mining area of Congo(DRC) contains 2.21% Cu and0.16% Co, which elements have reached the industrial recovery standard.In order to determine a reasonable and efficient beneficiation process, the ore property analysis and beneficiation test research are carried out.The results show that the types of the target minerals in the sulfur-oxygen mixed type copper cobalt ore are complex.Besides copper sulfide and copper oxide, some copper occurs in the form of copper in the copper manganese aluminum silicon oxide complex.Cobalt mainly occurs in the form of cobalt bearing pyrite and hydrocobaltite.At the same time, the gangue minerals are mainly carbonate gangues which are easy to mud.Combined with the results of ore property analysis and exploration condition tests, the beneficiation process of sulphide flotation-sulfide sulfide of oxide minerals by sodium sulfide-flotation of oxide minerals with combined collector collaborative collectors and high gradient strong magnetic separation of oxide flotation tailings was determined.According to the floatability and magnetic difference of different types of target minerals, The copper sulfide concentrate, copper oxide concentrate and magnetic separation concentrate were produced in different stages.The recovery rate of total copper and cobalt of the three products reached 91.54% and 56.48%, respectively, which realized the comprehensive recovery of the main target elements of the sulfur-oxygen mixed copper cobalt ore.