Abstract: Low-grade uranium resources are abandoned in the process of uranium mine development, resulting in serious environmental pollution and resource waste. The conventional leaching technology cannot effectively extract uranium from low-grade uranium resources such as low-grade uranium primary ore, uranium tailings, uranium leaching slag, and uranium-containing waste slag. Therefore, the enhanced leaching technology of low-grade uranium resources extraction attracts more attention. The research progress of eight leaching technologies and leaching mechanisms including oxidation leaching, roasting leaching, microwave-assisted leaching, ultrasonic-assisted leaching, microbial leaching, and pressure leaching are introduced. The green and efficient research direction of low-grade uranium resources leaching technology is summarized, which provides a reference for improving the uranium leaching rate and solving the problem that conventional technology cannot effectively extract uranium from low-grade uranium resources.