Abstract: Guizhou is known as the "hometown of barite", whose proven barite reserves are as high as 124 million tons, accounting for 34% of China's proven barite reserves, ranking first in China. In this paper, the mineral composition, chemical composition, whiteness, hardness, density, thermal properties and acid and alkali resistance of barite ore in Guizhou province were studied, and the suggestions for the development and utilization of barite ore in various regions were put forward. The results showed that the content of BaSO₄ was more than 80% in the barite ore in Zhenning County, Tianzhu County, Majang County, Guizhou Province. The main gangue minerals in the ore were quartz, dolomite, calcite, etc. Among them, the barite in Majang and Kaili had high whiteness, which was used as fine barite powder and chemical industry after acid leaching and roasting. The barites in Majiang had high density and could be used as barite for drilling. The barite in Tianzhu had the highest purity, the least impurities, could be directly used in the chemical industry. The content of SiO₂ in Zhenning samples is high, and its industrial application should be considered after silicon removal.