Abstract: The use of reasonable reagents in flotation process can effectively separate the increasingly poor, fine and miscellaneous ilmenite ore. Cationic, anionic and combined collectors, organic and inorganic inhibitors, metal ions and potassium permanganate activators are reviewed. Compared with the traditional collectors, the combined collectors improve the separation index of ilmenite to a certain extent due to the synergistic effect between the reagents, but the problem has not been properly solved. It is necessary to continue to strengthen the research and development and breakthrough of new reagents. The combination of anionic and cationic collectors has good development prospects. Inhibitors prevent the adsorption of collectors on gangue minerals by reducing the surface active sites of gangue minerals.Organic inhibitors and combination inhibitors show excellent sorting characteristics, and are the key research directions in the future. By increasing the number and activity of active sites on the mineral surface, the activator enhances the adsorption of the collector on the target minerals, but there is a pollution problem. The research on green and environmental friendly activator should be strengthened in order to put the activator into production as soon as possible and improve the industrial production efficiency.