Abstract: The fluid inclusions in high purity quartz sand limit its application. Quartz veins from a certain region in Africa as the research object, and flotation experiments were conducted on quartz particles with rich fluid inclusions. Quantitative analysis of fluid inclusions was conducted using DECA (Double Extreme Case Analysis) method, and it was found that the proportion of transparent quartz particles varied among different particle sizes of quartz sand. Flotation experiments were conducted on quartz sand with particle sizes of −0.20+0.106 mm. The results showed that when the pH was 9.5, the combined collector of BQY+HQY were 80+160 g∙t⁻¹, the proportion of transparent particles in the quartz concentrate was 65.46%, with an increase of 20.46 percentage points compared to the original ore. The proportion of transparent particles in the scanned concentrate increased by 10.08 percentage points compared to the original ore. Moreover, the content of Al、Fe、K、Ca elements in the concentrate decreased by 9.74%, 13.68%, 18.63%, and 18.96% compared to the original ore. According to infrared spectrum and energy spectrum analysis, the synergistic effect between BQY and HQY agents makes it easier for transparent quartz to float out. In addition, the bubble content in the quartz glass prepared before and after flotation had changed. It also further proves that flotation had the significant removal effect on rich fluid inclusion quartz particles.