Abstract: Based on the resource utilization of phosphogypsum, a kind of spherical calcium carbonate was prepared by chemical leaching-carbonization method. The single factor experiment of leaching and carbonization of phosphogypsum was carried out. The experimental results showed that the optimal extraction conditions of phosphogypsum were as follows: sodium acetate concentration of 4 mol/L, liquid-to-solid ratio of 25∶1 mL/g, salt leaching temperature of 50 ℃, salt leaching time of 30 min. The optimal carbonization conditions were as follows: ammonia concentration 15 mL, CO₂ flow rate 80 mL/min, carbonization temperature 30 ℃, carbonization time 60 min. The crystal phase of the product was vaterite, and the morphology of the product was spherical. After 8 cycles of sodium acetate auxiliaries, the reaction efficiency of calcium carbonate production was 57.8% after two cycles of sodium acetate auxiliaries. This study provides a new method for phosphogypsum comprehensive utilization and calcium carbonate production.