Abstract: Purification process study was conducted on quartz sandstone ore in Anhui province to remove the impurities. By the process of crushing, high temperature calcination, water quenching, magnetic separation, flotation and acid leaching, and the purification effects were investigated by calcination temperature, magnetic field intensity, flotation agent dosage, mixed acid type and acid leaching time. As the result of full-process experiment, Crushing magnetic separation by high temperature calcination at 900 ℃ and flotation with collectors NaOL, DDA and depressant Salufer and acid leaching in mixed acid (15% HCl+10% HNO₃+5% HF) for 6 h, the purity of SiO₂ was increased from 93.35% to 99.92% and content of impurity elements was reduced from 6.65% to 0.08%. The process has a significantly effect on the purification of quartz sandstone ore in this mine, which has reached the standard of raw material for the production of high transmittance solar photovoltaic glass, and provides a certain reference basis for the purification of quartzite ore.