Abstract: Kaolinite exhibits excellent chemical inertness, a tunable specific surface area, and modifiable surface functional groups. Its combination with functional components, such as iron oxide, enhances its adsorption capacity, regulates its selectivity, and improves its stability. This study optimized the adsorption conditions for tungsten (W) removal using iron oxide−loaded kaolinite as the adsorbent. A response surface methodology based on a Box−Behnken design was employed, with solution pH, initial W concentration, temperature, and reaction time as the influencing factors. The results indicate that the optimal conditions are: pH 3.1, an initial W concentration of 194 mg/L, a temperature of 39.7 ℃, and a reaction time of 3.1 h. Under these conditions, the predicted maximum W adsorption rate was 85%, which differed from the experimental value by a mere 0.23 percentage points. These findings demonstrate the potential of scaling up these mineral composite structures for engineering applications, offering a green, efficient, and sustainable solution for soil and water remediation.