Abstract: Iron sulfide minerals are widely associated with non−ferrous metal sulfide ores, and efficient, clean and low−cost separation has always been a challenge. High alkaline medium flotation separation is a conventional beneficiation process, but it has adverse effects such as low resource recovery, high environmental pollution and high cost. The low alkaline medium flotation of non−ferrous metal sulfide ore ore is been developed and improved, showing better applicability and superiority, which has gradually become one of the conventional flotation processes for non−ferrous metal sulfide ore. Based on this, the main problems in high alkaline medium flotation were analyzed, and the main processes of low alkaline flotation were summarized. The application progress of low alkaline medium flotation separation for non−ferrous metal sulfide minerals such as galena, sphalerite, chalcopyrite, and molybdenite was elaborated in detail. In summary, it is pointed out that the key to the low alkaline medium flotation of non−ferrous metal sulfide ores is to choose low alkaline depressants for iron sulfide minerals and high selective collectors for non−ferrous metal sulfide minerals. low alkaline conditions can maintain the natural floatability of non−ferrous metal sulfide minerals and make it easy to activate and reselect after inhibiting iron sulfide minerals, making the ore dressing recovery sufficient. The use of highly selective collectors can even achieve the flotation separation of non−ferrous metal sulfide minerals and iron sulfide minerals without the need for depressants and activators of iron sulfide minerals, and achieve the recovery of iron sulfide minerals from flotation tailings of non−ferrous metal sulfide ores using with xanthate.