Abstract: Phosphogypsum is a bulk solid waste produced by the wet phosphoric acid process, and is still mainly disposed of by centralized stockpiling, the large amount of phosphogypsum stockpiling may lead to serious environmental problems. In this paper, experiments on flotation and acid leaching conditions were carried out using phosphogypsum from a phosphate fertilizer producer in Hubei as raw material. The results showed that under the conditions of dodecylamine dosage of 200 g/t, slurry pH value of 2.0, 5% sulfuric acid liquid−solid ratio of 5∶1, acid leaching time of 2 hours, and acid leaching temperature of 35 ℃, phosphogypsum concentrate with a whiteness of over 70% and a CaSO₄·2H₂O purity of over 97% can be obtained. Soluble phosphorus and fluorine are reduced to 0.098% and 0.052%, respectively. Zeta potential, surface tension The FT−IR spectrum analysis shows that the dodecylamine flotation agent mainly exhibits hydrogen bonding and physical adsorption on the surface of phosphogypsum, and the silicon dioxide content in the concentrate significantly decreases after flotation. This process has strong applicability, simple operation, and can provide raw materials for the high value−added resource utilization of phosphogypsum.