Abstract: Graphene showns promising prospects due to its unique structural characteristics and excellent physicochemical properties. In this paper, graphite tailings in Luobei were taken as the research object, and graphite nano/microsheets were extracted from graphite tailings by grinding, ultrasound and gravitational settlement, followed by purification and exfoliation to prepare graphene. The results showed that the tailings particles with d₅₀ of about 2.5µm were obtained by grinding, ultrasonic stripping was performed for 6 min, and the graphite was enriched by gravitational settlement. The yield of recycled graphite microsheets was 9.72%, and the recovery rate was 80%. After purification, graphite nano/microsheets were obtained with fixed carbon content of 98.1% and about 20 layers. Finally, the high pressure microjet homogenizer was used to exfoliate and prepare multi−layer graphene. The ratio of graphite nano/microsheets, water and dispersant was 0.2 mg∶1 mL∶0.001 mg, and the pressure of the high pressure microjet homogenizer was 80 Mpa. After 25 high−pressure dispersion cycles, the thickness of the graphene sheets was less than 10 layers and the diameter of the sheets was more than 3 μm to produce graphene with high crystal quality. The preparation of graphene from graphite tailings not only expands the range of graphene raw materials but also realizes the resource utilization of graphite tailings.