Abstract: The granularity of a molybdenum cleaner tailings from Henan Province was fine, with −23 μm grade accounting for 65%. The Cu and Mo grades of the tailings were 0.20% and 0.08%, respectively, which had a certain recovery value. PADD flocculant was synthesized by introducing hydrophobic monomer − dodecyl gluconide on acrylamide, which had a good hydrophobicity. In the work, PADD was used as flocculant to recovery fine Cu−Mo sulfide ore from the molybdenum cleaner tailings via selective flocculation flotation. Under the conditions of pulp pH 4.2, the dosages of sodium hempetaphosphate, PADD, cupric sulfate, kerosene, ethylthiamine and 2# oil were 500 g/t, 150 g/t, 100 g/t, 170 g/t, 151 g/t and 60 g/t, respectively, the closed circuit of once roughing flotation, once scavenging flotation, twice cleaning flotation, and the middles I, II and III were combined return to the roughing flotation were performed. The obtained final mixed concentrate had the Cu grade of 12.054%, Cu recovery of 89.98%, Mo grade of 3.214%, and Mo recovery of 64.20%, which efficiently comprehensive recovered the valuable Cu and Mo from the molybdenum cleaner tailings. Based on the strong hydrophobicity, PADD selectively flocculated micro−fine copper molybdenum sulfide ore mainly through the hydrophobic force, and then significantly improved the selective flocculation flotation effect of micro−fine copper molybdenum sulfide ore in molybdenum tailings.