Abstract: In order to recover manganese and silver from silver tailings, the mineral composition and dissemination characteristics of the principal minerals were investigated. The results showed that the manganosiderite was the main mineral with fine particle size, and typically generated as aggregates with particle sizes ranging from 38 to 150 μm, and has a liberation degree of 81.95%, with rich aggregate dominating the unliberated component. A combination of flotation and leaching methods was employed based on the process mineralogical characteristics of the tailings. As a result, a manganese concentrate was obtained with an Mn grade of 17.89% with the recovery rates of 67.99%, an Ag grade of 104.1 g/t with the recovery rates of 55.15%. Under optimal leaching conditions, the manganese leaching rate reached 98.11%, with a total manganese recovery of 66.70%. The silver leaching rate from manganese leaching residue was 95.61%, with a total silver recovery rate of 52.73%. The comprehensive recovery of associated manganese resources from silver tailings not only improves the comprehensive utilization level of resources, but also improves the economic benefits of mining enterprises.