Abstract: Tin is an indispensable key strategic metal in modern industry. In China, Tin ore resources are abundant, however, with the depletion of high−quality tin ore, the characteristics of tin ore resources being poor, fine, and mixed are becoming increasingly prominent. The presence of fine particles and complex components has become a significant technical challenge in the recovery of tin ore resources. Flotation, as the primary method for recovering fine cassiterite, demands a crucial selection of flotation reagents. In this paper, the characteristics and mechanisms of common fatty acid collectors, arsenic acid collectors, phosphate collectors, alkyl sulfosuccinic acid collectors, and hydroxamic acid collectors were summarized. The application results of novel hydroxamic acid collectors in cassiterite flotation and the combination of collectors, activators, and inhibitors in cassiterite flotation were emphatically introduced, which provide a reference for the development of new reagents in cassiterite flotation.