Abstract: Chalcopyrite is always associated with sulfide minerals, oxide minerals and gangue minerals in nature. In bioleaching systems, the ions dissolved from these associated minerals, the galvanic effect, and the influence on the redox potentials of chalcopyrite leaching solution will affect the leaching efficiency of chalcopyrite. This paper reviews the research status of the effects of chalcopyrite co-associated minerals on its bioleaching from gangue minerals, metal sulfide minerals and metal oxide minerals, aiming to provide theoretical support for improving the leaching efficiency of chalcopyrite and provide some inspiration for the efficient separation of other refractory sulfide ores.