Abstract: Compared with the traditional crushing equipments, the high-pressure roller mill (HPGR) has the advantages of high crushing efficiency, low unit energy consumption, and directly discarding tailings for grinding products. Taking the Qidashan lean hematite ore as the raw materials, the particle size distribution of grinding products, grinding technical efficiency, and Bond work index of ball mill of HPGR products and cone crushing (CC) products were investigated to compare the grinding performance of different crushing products. The results showed that compared with CC, the content of coarse particles in the follow-up grinding products decreased and the content of fine particles increased using HPGR under the same grinding conditions. The +0.15 mm size fraction decreased 9.41 percentage points after 9 min grinding, while the −0.031 mm increased 6.45 percentage points When the content of −0.074 mm particles in grinding products was lower than 70%, the grinding technical efficiency of HPGR products was lower than that of CC products. When the content of −0.074 mm particles in grinding products reached 80% or above, the grinding technical efficiency of HPGR products was slightly higher than that of CC products. The energy consumption of HPGR products was obviously lower than that of CC products. The Bond work index of ball mill of HPGR products was 2.74 to 10.84 percentage lower than that of CC products under different control sieve size conditions. This study provides a guidance for the HPGR application in ore comminution.