Abstract: The quartz from Gansu (GS) and Hubei (HB), which were generated in different ore-forming conditions, were used for the comparative purification research by the same beneficiation process. The reasons for the different purification results were analyzed by XRF and Polarized Light Microscopy. The results showed that: (1) The products with SiO₂ content of 99.68%(GS), 99.65% (HB) and Fe₂O₃ content of 58.62 μg/g (GS) and 79.46 μg/g(HB) could be obtained respectively by crush−screen−grinding−magnetic separation−acid leaching process for the two samples , which could be used for photovoltaic glass production. (2) The iron removal rates of HB sample in the magnetic separation and flotation processes were 81.92% and 17.41% respectively, which were better than those of GS samples at 75.61% and 10.37%. Because the iron content of HB sample was lower than that of GS sample. What’s more, for the HB sample, it had more free iron, and a larger amount of iron impurities were stored in sericite feldspar and clay minerals, which were easily removed by magnetic separation and flotation. (3) The iron removal rate of GS sample under the best acid leaching condition was 86.74%, which was better than 66.97% of HB sample. The reason was that the fine−grained quartz population in GS sample contain was bigger than that in HB sample, and a large number of iron−containing impurities such as white muscovite and sericite were endowed in the population fractures, which were more easily removed by the acid leaching process.