Abstract: The disseminated copper-nickel oxide ore in Xinjiang contained 0.89% copper and 0.55% nickel. An in-depth study of the ore properties was carried out to develop and utilize this mineral resource. According to the results, the industrial type of ore belonged to ultrabasic rock weathering crust type copper-nickel ore, and copper was mainly in the form of malachite and chrysocolla, and nickel was mainly exsited in chlorite. The oxidation rates of copper and nickel were 74.16% and 96.57% respectively. The ore was severely weathered and contained large mud, which belonged to a refractory copper-nickel oxide ore. Based on the study of ore properties, comparative tests of flotation, agitation leaching and pool leaching were carried out. The results showed that the recovery of copper and nickel by pool leaching was better. When the grinding fineness was -0.074 mm accounting for 45%, the pulp concentration was 20%, sulfuric acid dosage was 50 g/L and leaching time was 24 d, the copper leaching rate was 81.27% and the nickel leaching rate was 60.32%. The copper-nickel leaching solution was treated by a method of copper replacement with iron - iron neutralization -nickel precipitation with sodium sulphide ,and the sponge copper grade was 92.05%, copper replacement rate was 97.35%, nickel grade in nickel sulfide was 24.32%, and nickel precipitation rate was 86.78%. Finally, the recovery rate of copper was 79.12%, and the recovery rate of nickel was 52.35%. The process serves as a technical basis for the development and utilization of the mine, as well as a reference for the development and utilization of the same type of copper-nickel oxide ore.