Abstract: The development and utilization of lead oxide ore has attracted wide attention due to the decreasing of lead sulfide resources. The difficulty of lead oxide ore flotation is its low floatability and complex composition, and sulfation can solve this problem by improving the floatability of lead oxide ore. In this paper, the ore properties of lead oxide ore and the development and application status of flotation reagents are introduced. Taking direct flotation method and sulfurization-xanthate method as the starting point, the research progress and current problems of lead oxide flotation technology at home and abroad in recent years are reviewed. The research direction of lead oxide flotation is prospected. The purpose is to provide some reference for efficient and clean flotation separation of lead oxide ore.