Abstract: A new process of "gravity separation-flotation-acid leaching" purification was proposed for the removal of iron and titanium from a quartz sand in Sichuan. Fe and Ti were removed preliminarily from quartz sand by gravity separation and flotation, then purified by two-stage acid leaching. The gravity separation was performed by one roughing-one cleaning two-stage spiral chute to remove Fe and Ti, and the flotation was performed by one roughing- one scavenging to remove rutile mainly containing Ti mineral. Quartz sand was leached firstly with "hydrochloric acid of 3 mol/L + acetic acid of 1 mol/L + hydrofluoric acid of 0.5 mol/L" at 70 ℃ for 2 h, and secondly with "hydrochloric acid of 3 mol/L + sulfuric acid of 1.5 mol/L" to obtain the final concentrate. The content of SiO₂ increased to 99.92%, Fe and Ti contents decreased to 0.005% and 0.012% respectively, and the removal rate of Fe and Ti reached 91.80% and 71.43% respectively in concentrate. The process has remarkable effect on the removal of iron and titanium in quartz sand, and has reference value for mining and utilization of similar ores.