Abstract: The difficulty of scheelite flotation is mainly the separation of calcium-containing gangue minerals. To achieve the separation of scheelite and calcium-containing gangue minerals, it is necessary to selectively collect scheelite and selectively inhibit calcium-containing gangue minerals. This paper analyzes the difficulties of scheelite flotation, introduces the development status, mechanism of action, reagent combination and practical application of relevant collectors and regulators with flotation reagents as the breakthrough point, and objectively evaluates the advantages and disadvantages of various reagents. The development of scheelite flotation reagents in the future is envisioned, aiming at achieving efficient flotation enrichment of scheelite, reduce production costs and reduce environmental pollution.