Abstract: Barite is a strategic non-metallic mineral resource, which occupies an important position in national economic and social development. This paper briefly describes the distribution, reserves and production of barite mineral resources in the world and China. The development of barite separation process in recent years is summarized emphatically. In addition, the collectors and depressants in the flotation separation of barite are also described in detail. In the long run, it is particularly important to separate barite from associated ore, low grade ore and tailings by combined separation process and combination of reagents to ensure the sustainable supply of barite resources, which is bound to become the research focus of comprehensive utilization of barite resources.