Abstract: Quartz is often symbiotic with feldspar silicate minerals, which is difficult to separate and purify because of their similar physical and chemical properties. Flotation is the most effective method for the separation of quartz and feldspar. The main flotation methods for the separation of quartz and feldspar, such as hydrofluoric acid method, fluoride-free acid method and fluoride-free acid method, are reviewed in detail. It is pointed out that fluoride-free acid method and pretreatment enhanced flotation will be the key direction of technological development in the future. In pharmaceutical research, the current focus is on the design and development of combined cationic and anion collectors, inhibitors, metal ion activation and so on, but the mechanism research is less.