Abstract: The research of flotation reagent is the important direction of rutile flotation technology.The influence and mechanism of salicylhydroxamic acid, benzohydroxamic acid and octanohydroxamic acid on the flotation of rutile has been investigated through single mineral flotation experiments, scanning electronic microscope, infrared spectroscopy, contact angle test and reagent adsorption analyses. The results indicated that salicylhydroxamic acid, benzohydroxamic acid and octanohydroxamic acid has good collection performance for rutile pure mineral when pH value is 6.5, 6.5 and 5.5 respectively.Rutile adsorbed hydrophobically with three hydroxamic acids, butthe hydrophobicity of benzylhydroxamic acid was the best, the recovery was 82%.