Abstract: For the Hua Yangchuan low-grade uranium niobium lead polymetallic ore, the valuable metals in the ore were preconcentrated by gravity separation, and the slime of ore was reduced by prescreening and stage grinding, which could improve the gravity separation recovery rate of valuable metals. Then the associated galena and magnetite were recovered from the gravity concentrate, and the lead concentrate and iron concentrate with qualified radioactivity and grade were obtained, which realized the comprehensive recovery of associated metals. Finally, benzohydroxamic acid was used as a collector to directly flotation betafite, and the uranium-niobium concentrate with high recovery and high grade was obtained. The final indicators were obtained with the lead concentrate yield of 0.67%, lead grade of 57.85%, lead recovery of 69.48%; iron concentrate yield of 3.05%, iron grade of 64.50%, iron recovery of 65.87%; uranium niobium concentrate yield of 1.76%, uranium grade of 0.702%, uranium recovery of 77.89%, niobium grade of 0.695%, niobium recovery of 72.55%.