Abstract: Cementitious material was prepared with skarn type iron ore tailings, slag, cement clinker and desulfurization gypsum. The effects of iron tailings content, water-binder ratio and water reducing agent content on mechanical properties of high strength structural materials were studied. The mechanism of hydration reaction of cementified material was also studied with XRD and TG-DSC. The results show that when the dosage of iron ore tailing powder is 30%, the water-binder ratios is 0.35, and the dosage of water reducing agent is 0.4%, the sample with 28 d strength up to 28.55 MPa can be prepared. There is synergistic hydration reaction of multiple solid waste in the cementing material system, which can promote the strength of the system to increase continuously.