Abstract: During the leaching of high-iron zinc calcine, the leaching of Zn will also lead to the dissolution of impurity Fe, affecting subsequent production and increasing economic costs. To solve this problem, the zinc calcine from an enterprise was taken as the research object. Through the study of The factors affecting the leaching rates of Zn and Fe such as stirring speed, leaching time, initial acidity and leaching temperature were analyzed. The leaching process was optimized. So as to improve the leaching rate of Zn and reduce the leaching rate of Fe. The results showed that under the conditions of leaching temperature of 60 ℃, initial sulfuric acid concentration of 120 g/L, liquid-solid mass ratio of 10:1, stirring speed of 500 r/min and leaching time of 60 min, higher Zn leaching rate and lower Fe leaching rate could be obtained. At this time the Zn leaching rate was 88.5%, and the Fe leaching rate was 10.3%.