Abstract: Gangue minerals of a low-grade scheelite mine in Hunan are mainly silicate minerals, calcite and feldspar. This dressing plant has problems such as long production process, low separation efficiency and low recovery rate. Therefore the flotation tests of scheelite were carried out by the combined separation process of cyclonic static micro-bubble flotation column and flotation machine.The optimal test conditions are as follows: treatment capacity of 25 kg/h, collector dosage of lead nitrate and MTC 900 g/t, aluminum sulfate 450 g/t and sodium silicate 600 g/t respectively. The results show that under the optimal conditions, a tungsten concentrate with a grade of 15.93% and a recovery of 79.02% was obtained using the technological process of one roughing, one cleaning and two scavenging. Compared with the whole flotation machine process and the whole flotation column process, the "column and machine combined process" can enhance the recovery of coarse and fine scheelite at the same time. The tungsten concentrate recovery rate increases from 48.5% of the whole flotation machine process and 68.74% of the whole flotation column process to 79.02%. Column machine combined process can not only realize effective recovery of scheelite, but also shorten the flotation process.