Abstract: Through the combination of weak magnetic separation and lead-antimony flotation in a lead-antimony-zinc polymetallic sulfide mine in Guangxi, excellent flotation indexes were obtained. To deal with the complex lead-antimony-zinc sulfide ore containing Pb 2.28 %, Sb 1.98 %, Zn 13.43%, closed-circuit tests indicated that was conducted, lead grade and recovery were 27.61% and 89.09%, respectively, and antimony grade and recovery were 23.76% and 88.78%, respectively, in lead-antimony concentrate with 5.47% zinc. Compared with the flotation indexes with ammonium dibutyl dithiophosphate, the grade of lead(Pb) and antimony(Sb) have increased by 2.10% and 0.95% respectively, while the recovery of Pb and Sb have increased by 2.76% and 3.65% respectively, zinc recovery rate reduced by 1.57%. Compared with the flotation indexes on-site process, the grade of lead(Pb) and antimony(Sb) have increased by 1.56% and 0.45% respectively, while the recovery of Pb and Sb have increased by 2.85% and 2.61% respectively, zinc recovery rate reduced by 1.14%.