Abstract: Based on the molecular design theory of flotation reagents and the structural theory of odor molecules, two amide xanthates—potassium potassium O-(2-acetamidoethyl) carbonodithioate and potassium O-(2-benzamidoethyl) carbonodithioate were designed and synthesized and their structure were characterized.These double ligand xanthates containing amido and xanthate groups were prone to produce hydrogen bond between the molecules, and the interaction between the double ligands could weaken the orienting effect of odor molecules on the surface of the olfactory receptors, thereby eliminating the malodor. The synthesis test showed that both potassium O-(2-acetamidoethyl) carbonodithioate and potassium O-(2-benzamidoethyl) carbonodithioate had no pungent odor of traditional xanthate.The single mineral flotation test demonstrated that the collection performance of potassium O-(2-benzamidoethyl) carbonodithioate was similar to that of ethyl xanthate, but better than that of potassium O-(2-acetamidoethyl) carbonodithioate, and the collection performance of pyrite was weaker than that of ethyl xanthate and stronger than that of potassium O-(2-acetamidoethyl) carbonodithioate.The adsorption capacity test showed that the order of the adsorption amount of the three collectors on the surface of chalcopyrite was consistent with the single mineral flotation results.The results of Zeta potential and infrared spectroscopy further indicated that the amido xanthate collector were chemically adsorbed on the surfaces of chalcopyrite and pyrite.