Abstract: A tin-copper-bearing polymetal tin ore in Yunnan contains 0.79% of copper, 38 g/t of silver, 43.6 g/t of indium, and 0.56% of tin. Its main minerals are chalcopyrite, pyrite, bornite and cassiterite. According to the properties of ore samples, the exploration and experimental study were carried out. The combined process of copper floatation-desulfurization flotation-magnetic separation iron removal-gravity tin separation was finally determined. The results show that the copper float process can obtain copper concentrates containing 21.98% copper, 694.5 g/t silver, and 265.17 g/t indium, and recovery rates of 92.92%, 66.2%, and 19.62%, respectively. The gravity separation can obtain tin concentrates containing 35.58% tin and 465.24 g/t indium, and the recovery rates of 77.42% and 46.52%, respectively, which realizes the comprehensive recycling of copper, silver, indium and tin.