Abstract: It is effective to enrich iron and reduce impurity for high phosphorus oolitic hematite in western Hubei through the process to fine grinding-reverse flotation, which can realize the recovery and utilization of iron. However, the turbidity of wastewater produced by this process was high and its compositions were complex, which makes it difficult to recycle the flotation wastewater. In this paper, the reverse flotation wastewater was studied, and the results showed that the pH value of the wastewater was 9.6, the scattering turbidity was 95 780 NTU, and the suspended matter concentration was 1 272 mg/L. The method of Calcium oxide (CaO) and polyacrylamide (PAM) combined coagulation precipitation was performed to treat the flotation waste water.. The treated wastewater with the turbidity of 19.9 NTU and the effluent rate from 80% to 90% can be obtained when the stirring time is 10 min with the stirring rate of 80 r/min, and the the dosage of CaO and PAM are 350 mg/L and 20 mg/L, respectively. It can be found from the Zeta potential and scanning electron microscopy that the addition of CaO-PAM can reduce the electrostatic repulsion between the suspended fine particles, which leads to the double electric layer adsorption. The fine particles are flocculated and precipitated by the bridging, which reduces the turbidity and metal ion content of waste water. It meets the requirements of recycling wastewater and reduces resource waste and environmental pollution hazards caused by wastewater discharge.