Abstract: Due to the fine particle size and difficult settlement of tailings, the efficient settlement and concentration of tailings has become an increasingly important topic.In order to improve the sedimentation rate and improve the water quality of tailings, research on two kinds of inorganic polymer flocculants, and the dosage of the two kinds of organic polymer flocculant effect on flocculation concentration tailings, according to the flocculation effect, two kinds of flocculants for drug distribution, the corresponding flocculation sedimentation experiment floccules and microscope image analysis, and discussed the flocculation mechanism, aims to reveal the inorganic flocculants, organic flocculants and composite flocculants on flocculation effect.The results show that for flotation tailings of lead-zinc sulfide ore, the inorganic flocculant has a significant effect on reducing the turbidity of supernant solution, and the polyferric sulfate (PFS) is better than the polyaluminum chloride (PAC) in improving the settling rate. Organic flocculants have a prominent effect on increasing the sedimentation rate, and cationic polyacrylamide (CPAM) is obviously better than anionic polyacrylamide (APAM) in removing turbidity. PFS-CPAM composite flocculant can not only ensure the turbidity removal effect, but also greatly improve the sedimentation rate, and is better than two single flocculants.