Abstract: The wastewater of lead-zinc mineral processing plant is characterized by large amount, complex components of pollutants and various toxic and harmful substances. Therefore, it is difficult to deal with up-to-standard discharge or recycling. Qixiashan lead-zinc mine and Huize lead-zinc mine are taken as the research object. The ore properties, mineral processing technology and flotation reagents are summarized. The source and end treatment reusing of beneficiation wastewater are compared and analyzed. The effect of zero discharge of beneficiation wastewater is described. Based on the comparative analysis, it can be concluded that the treatment and reuse of beneficiation wastewater should be taken into consideration in the process of selection and formulation of mineral processing technology. The source separation and reuse of beneficiation wastewater are the most economic and effective way. On the basis of the separation and reuse of mineral processing wastewater from the source, moderate treatment and even advanced treatment and reuse of beneficiation wastewater can not only improve the efficiency of beneficiation wastewater treatment and reuse and reduce the cost of treatment and reuse, but also achieve the goal of zero discharge of beneficiation waste water.