Abstract: Grinding is a complex physical and chemical process, which affects the flotation behavior of minerals by changing the mineral surface properties and slurry properties. In the process of grinding, different grinding methods, grinding media, grinding fineness and the addition of reagents will affect the flotation behavior of minerals. The mechanism of grinding affecting mineral flotation was summarized from three main aspects: electrochemistry, solution chemistry and mechanical chemistry. Grinding aids improve the content of qualified particles in grinding products, significantly improve grinding efficiency and reduce energy consumption. The influence of grinding aids on grinding flotation system under different grinding conditions is reviewed. The future development direction of grinding aids was prospected.