Abstract: Phosphogypsum is a by-product of phosphoric acid industrial production, and its stacking volume is increasing year by year, which brings a great threat to the environment and agricultural safety. The way of comprehensive utilization of phosphogypsum was described, and the mechanism of phosphogypsum producing cement, preparing ammonium sulfate, potassium sulfate and alkaline soil conditioner was analyzed. It is proposed that carrying out the research on key common technology innovation of comprehensive utilization and source emission reduction technology of phosphogypsum, realizing the harmless, resource-based and high-value utilization of phosphogypsum.