Abstract: Copper-nickel sulfide ore is the most important resource of nickel in China. The characteristics of copper-nickel sulfide ore resources were introduced. The several common flotation processes were mentioned in detail with their advantages and disadvantages. In terms of reagent, the relevant regulators, collectors and frothers were explained and their research status was summarized. Finally, the development of improving the comprehensive utilization rate of copper-nickel sulfide ore was forecasted.