Abstract: The flotation of copper oxide ore was divided into direct flotation and sulfide flotation according to the different ore properties and reagent systems. The commonly used collectors of copper oxide mainly include xanthine and its derivatives, fatty acids, phosphonic acids, hydroxamic acids, chelates, etc. In this paper, the research progress and application of the combination collectors and new collectors for copper oxide flotation method were reviewed, which provided a reference for the flotation agent system of copper oxide.