Abstract: Oxime compounds, which have unique chemical reactivity, can coordinate with a variety of metal ions and have broad application prospects. The structures and properties of oximes, including aldoxime, ketoxime, hydroxamic acid and amidoxime, were reviewed. The synthesis methods of new multi-functional chelating oximes, such as carboxyl hydroxamic acid, amide-alkylhydroximic acid, thiol oxime, olefin oxime, amino amidoxime, bis(amidoxime) and oxime polymer, and the improvement of traditional oxime compounds were introduced. The updated progress of their application in the fields of flotation and metallurgy were also reviewed.