Abstract: Many sulphide ore often coexist with magnesium silicate minerals such as talc. Due to its good floatability, talc causes difficulties in flotation separation of sulfide ore, affecting the comprehensive index of sulfide ore dressing. For such sulfide ore, it is often achieved by inhibiting talc. Flotation separation, so it is of great significance to study talc inhibitors and their mechanism of action. In this paper, the research progress of talc inhibitors is reviewed. The talc inhibitors are classified into inorganic and organic. Inorganic inhibitors such as water glass and sodium hexametaphosphate are widely used in sulfide ore flotation. The inhibition mechanism are as follows. The substance formed after hydrolysis is adsorbed on the surface of talc, which makes the talc hydrophilic; high molecular organic inhibitors such as CMC and Gur, have strong inhibition ability on talc and good selectivity. These agents mainly form hydrogen bonds through hydroxyl, carboxyl and talc. The chemical bond makes the talc hydrophilic, and realizes the flotation separation of sulfide ore and talc. The use of effective polymer inhibitors is the main direction for the separation of talc and sulfide ore flotation. In the polymer inhibitors, -OH and -COOH are the main functional groups for inhibiting talc. This is the modification, design and modification of talc inhibitors. Development provides the basis.