Abstract: Residual minerals in flotation wastewaters can promote the degradation of pollutants by the catalytic ozonation. In this work, the catalytic ozonation of O-isopropyl-N-ethyl thionocarbamate (Z-200) was investigated by sulfide minerals (pyrite, chalcopyrite, galena and sphalerite) and nonmetallic minerals (quartz, calcite, kaoline and montmorillonite), respectively. The results indicated that the dosage of minerals could increase the decomposition efficiency of Z-200 collector with an enhancement order of galena > pyrite > sphalerite > chalcopyrite (sulfide minerals) and kaoline > montmorillonite > calcite > quartz (nonmetallic minerals). In particular, the decomposition rate constant of Z-200 increased by 1.57 and 0.82 folds for the dosage of 0.5 g/L galena and kaoline into O₃ system, respectively. The O₃/mineral systems could enhance the decomposition of both Z-200 and its byproducts compared to O₃-alone. After the decomposition of Z-200, solution pH reduced from 10.0 to about 8.0 and the redox potential increased from -23 to about 200 mV. The mineral particles can promote the decomposition of O₃ molecules, generating much higher amounts of oxidative species. Mineral particles in flotation wastewaters are natural catalysts to form the catalytic ozonation systems in the removal of flotation reagents.