Abstract: The reverse flotation condition test was carried out on the magnetic concentrate of low-grade hematite ore from Anqian by using the ether amine-based compound collector DLT-Ⅰ and the modified starch depressant DLT-Ⅱ. The suitable chemical system was determined to be the pulp pH value of 9.0, the collector DLT-Ⅰ dosage of 125 g/t, and the depressant DLT-Ⅱ dosage of 300 g/t. Based on the conditional tests, the technical indexes of the flotation concentrate with the TFe grade of 67.01%, the iron recovery of 93.70%, and the tailings grade of 15.28% was obtained by the process of the reverse flotation closed process of one roughing-one cleaning-three scavenging, which provided a reference for the efficient development and utilization of low-grade hematite ore from Anqian.