Abstract: Research advances on the applications of nanotubular halloysite in medicine and biomedicine, nanocomposite, environmental pollution remediation and other fields are reviewed. The research status, challenges and prospects of halloysite in these fields are mainly discussed. Owing to its unique nanotubular structure and good biocompatibility, halloysite can be used for the delivery and controlled release of drugs, bioactive molecules, cosmetics, herbicides, antioxidants, corrosion inhibitors and flame retardants, showing its great promise in drug delivery, antimicrobial materials, self-healing polymers and regenerative medicine. Thus, halloysite is regarded as a very important non-metallic mineral resource with superiority of our country. The in vivo compatibility and cytotoxicity of halloysite for humans and the application of halloysite for the delivery of drugs and bioactive molecules (e.g., small interfering RNA) are research areas that need to pay more attention and devotion.