Abstract: The grade of zinc, copper, iron sulfur, gold and silver in a low-grade copper-zinc polymetallic ore is 1.93%, 0.35%, 7.85% 4.03%, 1.01 g/t and 13.05 g/t, respectively. In order to exploit and utilize this resource reasonably, systematic process mineralogy research has been carried out. The occurrence state of various valuable metal elements, the dissemination characteristics and dissemination size of various minerals, as well as the most important factors affecting the recovery had been found out, which provided a theoretical basis for determining reasonable process flow and realizing the comprehensive recovery. The comprehensive recovery of zinc, copper, sulfur and gold and silver in ore was obtained by the process of "preferential copper selection-copper middlings regrinding and cleaning-mixed sorting and resorting of zinc and sulfide-enrichment of gold and silver in copper concentration".