Abstract: In order to study the impact of mining activities on the eco-environmental change of Dachang gold mine concentration area in Qinghai Province, we use Landsat 5 TM, SPOT₅ and Gaofen 1 remote sensing data in 1988, 1996, 2004 and 2016 to interpret vegetation coverage using normalized difference vegetation index method, to be compared with the interpretation results of mining activities, and to explore the impact of mining activities on eco-environment in the historical period. The analysis shows that there is no obvious correlation between the eco-environment and mining activities in the mineral concentration area. Meteorological conditions are the main factors controlling the eco-environment of the mineral concentration area, and which are directive and intensive to the changes of eco-environment. Mining activity is the secondary superposition factor, and its change to eco-environment is partial and limited. In the future, it is feasible to carry out mining development activities in the mining area, and then build an ordered and efficient mining industry base on the premise of rational, orderly, large-scale and intensive development and utilization, which will have positive significance for driving local economic development.