Abstract: A scheelite ore with grade of WO₃ 0.68% in Ganshu, is typical refractory ore which is severely weathered ore containing limonite and carbonate. When the original production process was used to treat the ore, there were problems such as poor production and low recovery indicators. Based on the research of process mineralogy, conditional tests and key technologies for desliming were developed. through the multi-flow comparison tests, a beneficiation process suitable for the mine was developed. Adopting the ore-grinding classification-cyclone deslimimg -underflow flotation of sulfur-flotation of scheelite and heating- cleaning process, The sulphur product with syield of 2.75%, S grade 10.02% and S recovery of 81.00% and scheelite concentrate with yield of 0.81%, WO₃ grade 68.80% and recovery of 81.87% were obtained. This technology can solve the operation along the line and can improve the production index.