Abstract: In the flotation of bertrsandite in Xinjiang with the grade of BeO 0.45%, the selectivity was a bit low and the grade of concentration is not quite high when single collector was used. In order to deal with the problem above, sodium oleate and benzohydroxamic acid were used together. It is found after optimizing the flotation condition tests that when the proportion of sodium oleate and benzohydroxamic acid was 9 GA6FA 1, they are mixed before adding to the pulp and in this condition the optimum flotation effect can be gotten. When the dosage of collector was 1 000 g/t and collector was added beforehand, beryllium concentrate with grade 10.22% could be received after four times open circuit concentration, which showed the better concentration effect and provided effective technological support for recovering similar bertrsandite. The solution chemistry results of mixed reagents showed that when the pH value of mixed solution was approximately 8.25, the molecular concentration of benzohydroxamic acid is quite similar to ion concentration, which may results in assembly synergy.